Ribociclib (LEE011): Mechanism of Action and Clinical Impact of …
WEBJul 2, 2017 · The cyclin D–cyclin-dependent kinase (CDK) 4/6–p16–retinoblastoma (Rb) pathway is commonly disrupted in cancer, leading to abnormal cell proliferation. Therapeutics targeting this pathway have demonstrated antitumor effects …
Ribociclib (LEE011): Mechanism of Action and Clinical Impact ... - PubMed
WEBJul 1, 2017 · The cyclin D-cyclin-dependent kinase (CDK) 4/6-p16-retinoblastoma (Rb) pathway is commonly disrupted in cancer, leading to abnormal cell proliferation. Therapeutics targeting this pathway have demonstrated antitumor effects …
Ribociclib as First-Line Therapy for HR-Positive, Advanced …
WEBNov 3, 2016 · The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to endocrine therapy in advanced breast cancer that is positive for hormone receptor...
Overall Survival with Ribociclib plus Fulvestrant in Advanced …
WEBDec 11, 2019 · In the primary analysis of the trial, ribociclib plus fulvestrant resulted in significantly longer progression-free survival than placebo plus fulvestrant (median, 20.5 vs. 12.8 months; hazard...
Ribociclib plus Endocrine Therapy in Early Breast Cancer
WEBMar 20, 2024 · The absolute benefit with ribociclib plus an NSAI at 3 years was 3.3 percentage points. These results support the use of ribociclib in the treatment of HR-positive, HER2-negative early breast...
Use of Pharmacokinetic and Pharmacodynamic Data to Develop …
WEBJan 20, 2024 · Ribociclib (LEE011; Kisqali ®) is an orally bioavailable, highly selective, small-molecule, dual inhibitor of the CDK4/cyclin-D1 and CDK6/cyclin-D3 enzyme complexes. Ribociclib-based combinations are approved worldwide for the first- and second-line treatment of pre-/peri- and post-menopausal women with HR+, HER2− ABC, with a recommended ...
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits ...
WEBRibociclib is one of the selective CDK4/6 inhibitors and is a new therapeutic approach showing promise as a good strategy of therapy in many human cancers. However, there are not the studies regarding the investigation of effects of Ribociclib in cervical cancer yet.
Tissue/Site-Agnostic Study of Ribociclib for Tumors With Cyclin D …
WEBPurpose: As part of the Novartis Signature Program, this study evaluated the efficacy of ribociclib (selective cyclin-dependent kinase 4/6 [CDK4/6] inhibitor) in patients with cyclin D-CDK4/6 pathway-aberrant tumors.
Preclinical evaluation of ribociclib and its synergistic effect in ...
WEBMay 22, 2018 · Ribociclib is a specific cyclin dependent kinase (Cdk) 4/6 inhibitor that induces G1 arrest by blocking the formation of cyclin D1-Cdk4/6 complex and inhibiting retinoblastoma (RB)...
Intrinsic and acquired resistance to CDK4/6 inhibitors and ... - Nature
WEBJun 5, 2020 · Cyclin D-CDK4 could directly phosphorylate speckle-type BTB/POZ protein (SPOP) at Ser6, thereby promoting the physical interaction between 14-3-3γ and SPOP.
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