Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this ...

Researchers have developed an innovative CAR T-cell therapy to combat glioblastoma, the most common malignant brain tumor in ...

An international team led by Goethe University Frankfurt has identified an intracellular sensor that monitors the quality of so-called MHC-I molecules, which help the immune system recognize and kill ...

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins. A ...

Under this two-hit model, Brugge says, one normal copy of BRCA1 ought to be able to carry out DNA repair even when the other ...

T-cell therapy is a revolutionary immunotherapy approach in which T cells are genetically modified to express a receptor that ...

A new immune structure found in liver tumors could improve treatment for liver cancer patients. These structures are linked ...

Cancer-associated fibroblasts are cells that play a key role in the development and ... “Our molecular degrader, the ‘crowbar ...

November 11, 2024) There are processes in the human body that can suppress the growth and proliferation of cancer cells.

Novel method identified protein degraders that target Pin1, a protein involved in pancreatic cancer development.

Researchers from the Mattiroli group have found that the way DNA is packaged in cells can directly impact how fast DNA itself ...

Cancer-associated fibroblasts are cells that play a key role in the development and ... "Our molecular degrader, the 'crowbar,' opens up the structure of Pin1, its target," Pellecchia said. "We are ...