A clear case for distinct phenotypes of bone metastatic lesions is presented by the existence of osteolytic (bone resorbing) and osteoblastic (bone forming) tumors. A third category of lesions is ...

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A new MSK study is providing unique insights ...

the most common sites of metastasis were: bone (in 54.06% of those with metastatic cancer) lung (in 14.18%) liver (in 10.5%) brain (in 1.6%) Additionally, 19.67% of people had metastasis in ...

Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis. Researchers from Tampere University, Finland, and Izmir Institute of ...

RANKL expression is stimulated in osteoblasts and osteocytes by cytokines ... of RANK/RANKL by cancer cells is related to bone metastasis and aggressive behavior. Expression of RANKL is induced ...

The average time from consultation to treatment for bone metastases decreased by almost 4 days with virtual simulation ...

In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously ...

Raman is also a member of the Johns Hopkins Kimmel Cancer Center. “We first had to determine whether DDX3 was expressed in ...

Median overall survival (OS) increased from 19.3 months with upfront immune checkpoint inhibition (ICI) to 41.3 months when a ...

Teriparatide stimulates new bone formation on trabecular and cortical (periosteal and/or endosteal) bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity.

New research uncovers how the Clec14a protein in capillary endothelial cells controls bone growth and maturation, revealing a key mechanism in skeletal development. Study: Type-H endothelial cell ...

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A study is providing insights that researchers say point to therapeutic opportunities.