A clear case for distinct phenotypes of bone metastatic lesions is presented by the existence of osteolytic (bone resorbing) and osteoblastic (bone forming) tumors. A third category of lesions is ...

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A new MSK study is providing unique insights ...

the most common sites of metastasis were: bone (in 54.06% of those with metastatic cancer) lung (in 14.18%) liver (in 10.5%) brain (in 1.6%) Additionally, 19.67% of people had metastasis in ...

Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis. Researchers from Tampere University, Finland, and Izmir Institute of ...

RANKL expression is stimulated in osteoblasts and osteocytes by cytokines ... of RANK/RANKL by cancer cells is related to bone metastasis and aggressive behavior. Expression of RANKL is induced ...

The average time from consultation to treatment for bone metastases decreased by almost 4 days with virtual simulation ...

In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously ...

Patients with bone-predominant metastatic renal cell carcinoma (RCC) appeared to have better outcomes when they started ...

and lumbar spine BMD loss has been reported in PC patients without bone metastases (nonmetastatic PC). In prospective studies, concurrent administration of a bisphosphonate or selective estrogen ...

Teriparatide stimulates new bone formation on trabecular and cortical (periosteal and/or endosteal) bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity.

New research uncovers how the Clec14a protein in capillary endothelial cells controls bone growth and maturation, revealing a key mechanism in skeletal development. Study: Type-H endothelial cell ...

Metastasis remains the primary challenge to reducing cancer deaths worldwide. A study is providing insights that researchers say point to therapeutic opportunities.